Opioid Metabolites
نویسندگان
چکیده
منابع مشابه
Discriminative stimulus effects of intravenous heroin and its metabolites in rhesus monkeys: opioid and dopaminergic mechanisms.
Heroin has characteristic subjective effects that contribute importantly to its widespread abuse. Drug discrimination procedures in animals have proven to be useful models for investigating pharmacological mechanisms underlying the subjective effects of drugs in humans. However, surprisingly little information exists concerning the mechanisms underlying the discriminative stimulus (DS) effects ...
متن کاملDual Regulation of d-Opioid Receptor Function by Arachidonic Acid Metabolites in Rat Peripheral Sensory Neurons
The regulation of opioid receptor system function in peripheral sensory neurons is not well understood. Opioid agonist efficacy to inhibit nociceptor function and to promote antinociception is generally weak under basal conditions and frequently no response occurs. However, in response to a cyclooxygenasedependent metabolite of arachidonic acid (AA) after exposure to inflammatory mediators, suc...
متن کاملDual regulation of δ-opioid receptor function by arachidonic acid metabolites in rat peripheral sensory neurons.
The regulation of opioid receptor system function in peripheral sensory neurons is not well understood. Opioid agonist efficacy to inhibit nociceptor function and to promote antinociception is generally weak under basal conditions and frequently no response occurs. However, in response to a cyclooxygenase-dependent metabolite of arachidonic acid (AA) after exposure to inflammatory mediators, su...
متن کاملOpioid mechanisms and opioid drugs
C appreciate that there is interplay between the actions of the different subtypes of receptor and hence the value of drugs which target multiple receptor subtypes. Abstract The opioid system comprises four receptor subtypes: m (MOP), k (KOP), d (DOP), now called the ‘classical’ opioid receptors, and the ‘non classical’ nociceptin/orphanin FQ peptide (N/OFQ) receptor (NOP). Selective endogenous...
متن کاملMu Opioid Receptor Gene: New Point Mutations in Opioid Addicts
Introduction: Association between single-nucleotide polymorphisms (SNPs) in mu opioid receptor gene and drug addiction has been shown in various studies. Here, we have evaluated the existence of polymorphisms in exon 3 of this gene in Iranian population and investigated the possible association between these mutations and opioid addiction. Methods: 79 opioid-dependent subjects (55 males, 24...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Pain and Symptom Management
سال: 2005
ISSN: 0885-3924
DOI: 10.1016/j.jpainsymman.2005.01.004